This Friday evening, we’re excited to bring in two RNA experts, Dr. Liang-Yuan Chiu & Dr. Frank Fang-Yao Lee, to share how scientists develop RNA-targeted small molecules and how alternative splicing contributes to the development of inflammatory disorders. RNA-targeted small molecules have emerged as a potential avenue for drug discovery, offering unique advantages over traditional protein-targeted approaches. These molecules can modulate gene expression by targeting various types of RNA, including viral RNA, messenger RNA, non-coding RNA, and ribosomal RNA. The upcoming seminar will explore the potential benefits and obstacles of the RNA-targeted small molecule modality. Additionally, we will discuss utilizing structural insights to design innovative small molecule inhibitors that focus on RNA-targeted small molecules to combat hand, foot, and mouth disease.
RNA splicing is a fascinating molecular mechanism critical in disease development. For example, alternative splicing contributes to the development of inflammatory disorders like Acute Respiratory Distress Syndrome (ARDS) and Acute Myeloid Leukemia (AML). This Friday evening, we’ll explore the promising future of using these RNA mechanisms as innovative therapeutic approaches to combat these diseases.
🕗 Time: May 12, 2023 (Fri.), 8PM - 9PM ET
💻 Place: Zoom: https://tinyurl.com/BTBA23-RNA
💡 Topic: Pre-mRNA Alternative Splicing Regulation in Innate Immunity
🎤 Speaker: Frank Fang-Yao Lee, Ph.D., Postdoctoral Fellow at National Jewish Health
💡 Topic: Opportunities and challenges of RNA-targeted small molecule: A Case study on hand, foot, and mouth disease
🎤 Speaker: Liang-Yuan Chiu, Ph.D., Research Scientist in the Structural Biology and Biophysics department at Vertex Pharmaceuticals
🎙️ Moderator: Chih-Hsiang Yang, Ph.D., Postdoctoral Associate at UMass Chan Medical School