Chih-Chi Andrew Hu, PhD（胡志吉博士）
Associate Professor
Immunology, Microenvironment & Metastasis Program
The Wistar Institute/UPenn
Dr. Chih-Chi Andrew Hu earned his Bachelor’s degree from China Medical College and Master’s degree from National Sun Yat-Sen University. During his military service as a second lieutenant, he taught histology and performed research at the National Defense Medical Center. Dr. Hu pursued his doctoral training at the NYU School of Medicine to study membrane protein assembly on the surface of the urinary bladder. His doctoral work with Dr. Tung-Tien Sun, contributed to the understanding of how uroplakins assembled into 2-D crystals covering the entire bladder surface to form one of the best biological permeability barriers in nature. Dr. Hu pursued his postdoctoral training with Dr. Hidde L. Ploegh, at the Whitehead Institute/MIT, and later became an Assistant Professor at the Moffitt Cancer Center/University of South Florida. He was later recruited to the Wistar Institute/UPenn as an Associate Professor. Dr. Hu also served as a chair on the Cancer Biology Admissions Committee at UPenn to recruit promising young scientists for doctoral training. In Dr. Hu’s laboratory, investigators develop novel mouse models, biological reagents and chemical tools to investigate the functions of critical endoplasmic reticulum (ER) proteins in B cell development and differentiation as well as in malignant progression of B cell cancer. His laboratory also investigates how altered ER functions in cancer cells contribute to tumor immune evasion.